Track insider buy and sell

EDELMAN JOSEPH

various various 10% owner

1,500,000

$12.25

$1.8375E7

1.78886E7

N/A

S

2017-06-19

2017-06-19 16:08:35

Barth Jay

officer (Chief Medical Officer)

30,000

$10.00

$300,000.00

64,184

N/A

S

2017-05-19

2017-05-23 18:14:45

officer (Chief Science Officer)

29,914

$8.00

$239,312.00

474,438

N/A

S

2017-05-15

2017-05-17 17:01:14

officer (Chief Science Officer)

29,914

$8.00

$239,312.00

504,352

N/A

S

2017-03-02

2017-03-03 19:25:57

officer (Chief Operating Officer)

49,050

$8.00

$392,400.00

127,475

N/A

S

2017-02-07

2017-02-09 16:35:58

officer (Chief Science Officer)

25,000

$6.00

$150,000.00

534,266

N/A

S

2017-01-13

2017-01-17 16:15:34

officer (Chief Science Officer)

25,000

$6.00

$150,000.00

559,266

N/A

P

2016-12-30

2017-01-04 14:26:31

various various 10% owner

94,750

$4.96

$470,055.00

1.62938E7

N/A

P

2016-12-29

2016-12-30 08:46:25

various various 10% owner

94,750

$4.85

$459,916.00

1.62938E7

N/A

P

2016-12-28

2016-12-30 08:46:25

various various 10% owner

47,375

$4.91

$232,706.00

1.61991E7

N/A

P

2016-12-23

2016-12-27 10:58:31

various various 10% owner

37,900

$4.92

$186,582.00

1.61517E7

N/A

P

2016-12-23

2016-12-27 10:58:31

various various 10% owner

47,375

$4.72

$223,468.00

1.61138E7

N/A

P

2016-12-22

2016-12-23 08:31:46

various various 10% owner

189,500

$4.51

$854,834.00

1.60664E7

N/A

S

2016-11-09

2016-11-10 16:09:15

officer (SVP, Finance)

2,858

$8.00

$22,864.00

24,189

N/A

S

2016-11-09

2016-11-10 16:09:15

officer (SVP, Finance)

5,688

$8.00

$45,504.00

24,189

N/A

S

2016-11-01

2016-11-03 16:09:07

officer (Chief Science Officer)

25,000

$7.00

$175,000.00

533,453

N/A

S

2016-10-03

2016-10-04 20:22:06

officer (Chief Science Officer)

25,000

$7.25

$181,250.00

558,453

N/A

S

2016-09-20

2016-09-22 16:14:04

officer (Chief Financial Officer)

17,000

$8.00

$136,075.00

35,950

N/A

S

2016-09-20

2016-09-22 16:14:04

officer (Chief Financial Officer)

3,500

$8.00

$28,000.00

52,950

N/A

S

2016-09-06

2016-09-08 16:09:33

officer (Chief Science Officer)

25,000

$7.00

$175,000.00

583,453

N/A

S

2016-08-25

2016-08-26 16:31:34

various various other

1,100,000

$6.81

$7,491,000.00

1.41394E7

N/A

S

2016-08-04

2016-08-08 16:29:39

officer (Chief Science Officer)

25,000

$7.00

$175,000.00

608,453

N/A

S

2016-08-04

2016-08-08 16:28:35

Barth Jay

officer (Chief Medical Officer)

10,458

$7.00

$73,206.00

15,000

N/A

S

2016-07-27

2016-07-29 17:27:09

Barth Jay

officer (Chief Medical Officer)

20,916

$7.00

$146,412.00

25,458

N/A

P

2016-06-03

2016-06-13 19:12:21

Green Jeremy

various 10% owner

66,300

$7.20

$477,360.00

1.29564E7

N/A

P

2016-06-02

2016-06-06 16:09:43

Rosenberg Ellen

officer (General Counsel & Corp. Secy)

15,000

$7.67

$115,050.00

15,000

N/A

P

2015-11-10

2015-11-10 16:28:00

MCGLYNN MARGARET G

director

10,000

$10.27

$102,657.00

10,000

N/A

P

2015-10-07

2015-10-08 09:19:15

various various 10% owner

50,000

$6.27

$313,500.00

1.52394E7

N/A

P

2015-10-06

2015-10-07 10:29:03

various various 10% owner

7,000

$6.34

$44,380.00

1.51894E7

N/A

P

2015-10-06

2015-10-07 10:29:03

various various 10% owner

14,000

$6.47

$90,580.00

1.51824E7

N/A

P

2015-10-06

2015-10-07 10:29:03

various various 10% owner

14,000

$6.65

$93,100.00

1.51684E7

N/A

P

2015-10-06

2015-10-07 10:29:03

various various 10% owner

43,000

$6.34

$272,620.00

1.51544E7

N/A

P

2015-10-06

2015-10-07 10:29:03

various various 10% owner

86,000

$6.47

$556,420.00

15,111

N/A

P

2015-10-06

2015-10-07 10:29:03

various various 10% owner

86,000

$6.65

$571,900.00

1.50254E7

N/A

P

2015-10-05

2015-10-07 10:29:03

various various 10% owner

35,000

$6.76

$236,600.00

1.49394E7

N/A

P

2015-10-05

2015-10-07 10:29:03

various various 10% owner

35,000

$6.85

$239,750.00

1.49044E7

N/A

P

2015-10-05

2015-10-07 10:29:03

various various 10% owner

215,000

$6.76

$1,453,400.00

1.48694E7

N/A

P

2015-10-05

2015-10-07 10:29:03

various various 10% owner

215,000

$6.85

$1,472,750.00

1.46544E7

N/A

S

2015-10-01

2015-10-05 18:59:13

officer (Vice President Finance)

11,250

$13.13

$147,761.00

5,688

N/A

S

2015-10-01

2015-10-05 18:59:13

officer (VP, Legal & IP)

10,000

$13.14

$131,362.00

3,187

N/A

S

2015-09-21

2015-09-22 16:29:11

officer (Chief Financial Officer)

15,236

$16.78

$255,634.00

56,575

N/A

S

2015-09-21

2015-09-22 16:29:11

officer (Chief Operating Officer)

13,001

$16.78

$218,206.00

156,575

N/A

S

2015-09-15

2015-09-16 16:11:36

officer (Chief Science Officer)

25,000

$17.75

$443,668.00

720,953

N/A

S

2015-09-14

2015-09-16 16:08:44

officer (Vice President Finance)

2,500

$18.08

$45,200.00

5,688

N/A

S

2015-07-16

2015-07-20 16:15:43

director officer (Chairman & CEO)

16,025

$16.00

$256,400.00

83,499

N/A

S

2015-07-13

2015-07-15 17:06:27

officer (SVP, Pharmacology & Biology)

3,000

$15.00

$45,000.00

27,687

N/A

S

2015-07-13

2015-07-15 17:06:27

officer (SVP, Pharmacology & Biology)

2,500

$15.00

$37,500.00

27,687

N/A

S

2015-07-13

2015-07-15 17:06:27

officer (SVP, Pharmacology & Biology)

9,500

$15.00

$142,500.00

27,687

N/A

S

2015-07-13

2015-07-15 17:04:35

director

10,000

$15.00

$150,000.00

11,933

N/A

S

2015-07-14

2015-07-15 17:02:49

director officer (Chairman & CEO)

142,250

$15.03

$2,137,680.00

83,499

N/A

S

2015-07-13

2015-07-15 17:02:49

director officer (Chairman & CEO)

7,750

$15.01

$116,315.00

83,499

N/A

S

2015-07-08

2015-07-09 18:27:12

Doshi Dipal

officer (SVP Strategy & Bus Dev)

6,250

$13.87

$86,689.40

1,706

N/A

S

2015-07-01

2015-07-01 17:29:09

officer (Vice President Finance)

2,600

$13.98

$36,350.10

8,188

N/A

S

2015-07-01

2015-07-01 17:28:31

officer (VP, Legal & IP)

10,000

$13.98

$139,766.00

3,187

N/A

S

2015-07-01

2015-07-01 17:27:53

officer (SVP, Chief Patient Advocate)

10,649

$13.97

$148,818.00

5,693

N/A

S

2015-06-22

2015-06-24 19:08:34

officer (SVP, Pharmacology & Biology)

20,500

$13.85

$284,013.00

27,687

N/A

S

2015-06-22

2015-06-24 19:07:57

officer (SVP, Program Management)

18,981

$13.94

$264,627.00

25,000

N/A

S

2015-06-23

2015-06-24 19:07:07

HAYDEN DONALD J JR

director

55,000

$14.01

$770,390.00

0

N/A

S

2015-06-19

2015-06-23 20:10:05

officer (SVP, Technical Operations)

14,045

$13.26

$186,275.00

30,688

N/A

S

2015-06-19

2015-06-23 20:09:22

officer (Chief Operating Officer)

13,000

$13.26

$172,424.00

156,575

N/A

S

2015-06-19

2015-06-23 20:08:43

officer (Chief Financial Officer)

15,235

$13.26

$202,057.00

56,575

N/A

S

2015-06-15

2015-06-16 20:29:02

officer (SVP, Program Management)

7,377

$14.17

$104,532.00

0

N/A

S

2015-06-15

2015-06-16 20:15:43

officer (VP Clinical Ops & Data Mgmt)

8,195

$14.17

$116,123.00

0

N/A

S

2015-06-08

2015-06-08 16:54:33

director officer (Chairman & CEO)

55,000

$13.01

$715,550.00

83,499

N/A

S

2015-06-08

2015-06-08 16:54:07

officer (SVP, Program Management)

17,312

$12.87

$222,805.00

25,000

N/A

S

2015-05-11

2015-05-12 21:48:00

officer (SVP, Pharmacology & Biology)

8,000

$10.85

$86,810.40

2,687

N/A

S

2015-05-11

2015-05-12 21:48:00

officer (SVP, Pharmacology & Biology)

5,000

$10.84

$54,199.50

10,687

N/A

S

2015-05-11

2015-05-12 21:47:02

officer (VP Clinical Ops & Data Mgmt)

7,500

$10.85

$81,339.00

8,195

N/A

S

2015-05-11

2015-05-12 21:45:34

officer (VP Finance and Controller)

7,500

$10.84

$81,306.00

8,188

N/A

S

2015-05-11

2015-05-12 21:44:51

officer (VP, Legal & IP)

12,500

$10.84

$135,488.00

3,187

N/A

S

2015-05-11

2015-05-12 21:44:05

Kirk John

officer (VP, Regulatory Affairs)

10,000

$10.84

$108,358.00

5,687

N/A

S

2015-05-11

2015-05-12 21:43:13

officer (SVP, Chief Patient Advocate)

10,000

$10.84

$108,389.00

5,693

N/A

S

2015-05-11

2015-05-12 21:42:30

officer (SVP, Technical Operations)

10,000

$10.85

$108,450.00

5,688

N/A

S

2015-05-11

2015-05-12 21:41:51

officer (SVP, Program Management)

10,000

$10.84

$108,371.00

7,377

N/A

S

2015-05-11

2015-05-12 21:41:15

officer (Chief Operating Officer)

24,800

$10.84

$268,810.00

6,575

N/A

S

2015-05-11

2015-05-12 21:40:43

officer (Chief Financial Officer)

24,800

$10.84

$268,810.00

6,575

N/A

S

2015-04-15

2015-04-17 17:04:52

officer (VP, Pharmacology & Biology)

5,000

$12.50

$62,500.00

50,000

15.76%

S

2015-04-15

2015-04-17 17:04:35

director

20,000

$12.50

$250,000.00

11,933

15.76%

S

2015-04-10

2015-04-13 16:09:59

director officer (Chairman & CEO)

11,678

$12.00

$140,136.00

83,499

N/A

S

2015-04-01

2015-04-02 20:36:15

officer (VP, Program Management)

9,489

$10.69

$101,480.00

50,000

2.38%

S

2015-03-20

2015-03-25 08:00:06

officer (VP Clinical Ops & Data Mgmt)

7,785

$11.51

$89,585.10

50,000

-4.72%

S

2015-03-20

2015-03-25 08:00:06

officer (VP, Pharmacology & Biology)

1,708

$12.11

$20,683.90

50,000

0.50%

S

2015-03-20

2015-03-25 08:00:06

officer (VP, Pharmacology & Biology)

6,043

$11.68

$70,555.00

51,708

-3.21%

S

2015-03-20

2015-03-24 21:53:46

officer (VP, Pharmacology & Biology)

13,050

$11.53

$150,500.00

50,000

-4.49%

S

2015-03-20

2015-03-24 21:53:10

officer (VP, Legal & IP)

10,000

$11.52

$115,160.00

50,000

-4.64%

S

2015-03-20

2015-03-24 21:52:21

Kirk John

officer (VP, Regulatory Affairs)

10,110

$11.51

$116,359.00

50,000

-4.70%

S

2015-03-20

2015-03-24 21:51:36

officer (VP, Patient Advocacy)

10,648

$11.51

$122,568.00

50,000

-4.68%

S

2015-03-20

2015-03-24 21:51:16

officer (VP, Technical Operations)

14,045

$11.51

$161,669.00

50,000

-4.68%

S

2015-03-20

2015-03-24 21:50:33

director officer (Chairman & CEO)

268,322

$11.49

$3,082,240.00

83,499

-4.90%

S

2015-03-20

2015-03-24 21:49:53

officer (Chief Operating Officer)

12,999

$11.51

$149,595.00

200,000

-4.71%

S

2015-03-20

2015-03-24 21:49:28

officer (Chief Financial Officer)

15,235

$11.51

$175,294.00

100,000

-4.73%

S

2015-01-05

2015-01-05 17:32:58

officer (VP, Program Management)

4,667

$9.00

$42,003.00

50,000

15.44%

S

2014-12-04

2014-12-08 18:29:02

director officer (Chairman & CEO)

89,000

$8.36

$743,906.00

109,083

-3.01%

P

2014-12-04

2014-12-08 18:29:02

CEO

89,000

$8.36

$743,906.00

198,083

3.01%

S

2014-11-25

2014-11-25 17:44:02

officer (VP, Pharmacology & Biology)

25,000

$8.00

$200,000.00

50,000

0.75%

S

2014-11-25

2014-11-25 17:44:02

officer (VP Finance and Controller)

3,500

$8.00

$28,000.00

50,000

0.75%

S

2014-11-25

2014-11-25 17:44:02

officer (VP, Technical Operations)

7,000

$8.00

$56,000.00

50,000

0.75%

P

2014-11-25

2014-11-25 17:44:02

officer (VP, Pharmacology & Biology)

5,000

$8.00

$40,000.00

75,000

-0.75%

P

2014-11-25

2014-11-25 17:44:02

officer (VP, Pharmacology & Biology)

10,000

$8.00

$80,000.00

70,000

-0.75%

P

2014-11-25

2014-11-25 17:44:02

officer (VP, Pharmacology & Biology)

10,000

$8.00

$80,000.00

60,000

-0.75%

P

2014-11-25

2014-11-25 17:44:02

officer (VP Finance and Controller)

3,500

$8.00

$28,000.00

53,500

-0.75%

P

2014-11-25

2014-11-25 17:44:02

officer (VP, Technical Operations)

7,000

$8.00

$56,000.00

57,000

-0.75%

S

2014-11-25

2014-11-25 17:36:40

officer (VP, Legal & IP)

4,500

$8.00

$36,000.00

50,000

0.75%

P

2014-11-25

2014-11-25 17:36:40

officer (VP, Legal & IP)

4,500

$8.00

$36,000.00

54,500

-0.75%

S

2014-11-25

2014-11-25 17:35:44

officer (VP, Program Management)

8,103

$8.00

$64,824.00

50,000

0.75%

P

2014-11-25

2014-11-25 17:35:44

officer (VP, Program Management)

8,103

$8.00

$64,824.00

58,103

-0.75%

S

2014-11-25

2014-11-25 17:35:11

officer (Chief Operating Officer)

7,250

$8.00

$58,000.00

200,000

0.75%

P

2014-11-25

2014-11-25 17:35:11

COO

7,250

$8.00

$58,000.00

207,250

-0.75%

S

2014-11-25

2014-11-25 17:34:43

officer (Chief Financial Officer)

10,000

$8.00

$80,000.00

100,000

0.75%

P

2014-11-25

2014-11-25 17:34:43

CFO

10,000

$8.00

$80,000.00

110,000

-0.75%

P

2014-11-19

2014-11-19 14:55:55

various various 10% owner

2,100,000

$6.50

$1.365E7

1.44394E7

23.54%

S*

2014-10-27

2014-10-28 14:36:19

GLAXOSMITHKLINE PLC

other

1.13158E7

$5.29

$5.9872E7

0

-53.66%

S

2014-10-03

2014-10-06 17:19:42

officer (VP Clinical Ops & Data Mgmt)

3,200

$7.00

$22,400.00

50,000

17.71%

P

2014-10-03

2014-10-06 17:19:42

officer (VP Clinical Ops & Data Mgmt)

3,200

$7.00

$22,400.00

53,200

-17.71%

S

2014-10-03

2014-10-06 17:19:14

officer (VP Finance and Controller)

6,812

$7.00

$47,684.00

50,000

17.71%

P

2014-10-03

2014-10-06 17:19:14

officer (VP Finance and Controller)

6,812

$7.00

$47,684.00

56,812

-17.71%

S

2014-10-03

2014-10-06 17:18:45

officer (VP, Legal & IP)

13,853

$7.00

$96,971.00

50,000

17.71%

P

2014-10-03

2014-10-06 17:18:45

officer (VP, Legal & IP)

13,853

$7.00

$96,971.00

63,853

-17.71%

S

2014-10-03

2014-10-06 17:18:11

officer (VP, Program Management)

8,552

$7.00

$59,864.00

50,000

17.71%

P

2014-10-03

2014-10-06 17:18:11

officer (VP, Program Management)

8,552

$7.00

$59,864.00

58,552

-17.71%

S

2014-10-03

2014-10-06 17:18:04

officer (Chief Financial Officer)

10,000

$7.00

$70,000.00

100,000

17.71%

P

2014-10-03

2014-10-06 17:18:04

CFO

10,000

$7.00

$70,000.00

110,000

-17.71%

S

2014-10-02

2014-10-02 21:01:25

officer (VP, Program Management)

10,208

$6.01

$61,303.10

50,000

3.42%

P

2014-10-02

2014-10-02 21:01:25

officer (VP, Program Management)

10,208

$6.01

$61,303.10

60,208

-3.42%

S

2014-10-02

2014-10-02 21:00:14

officer (VP Clinical Ops & Data Mgmt)

4,759

$5.99

$28,514.00

50,000

3.20%

P

2014-10-02

2014-10-02 21:00:14

officer (VP Clinical Ops & Data Mgmt)

4,759

$5.99

$28,514.00

54,759

-3.20%

S

2014-09-29

2014-10-01 19:59:01

officer (Chief Financial Officer)

25,311

$6.09

$154,111.00

100,000

9.34%

P

2014-09-29

2014-10-01 19:59:01

CFO

25,311

$6.09

$154,111.00

125,311

-9.34%

S

2014-09-29

2014-10-01 19:57:12

officer (VP, Legal & IP)

28,208

$6.09

$171,804.00

50,000

9.37%

P

2014-09-29

2014-10-01 19:57:12

officer (VP, Legal & IP)

28,208

$6.09

$171,804.00

78,208

-9.37%

S

2014-09-29

2014-10-01 19:56:05

officer (VP Finance and Controller)

10,738

$6.10

$65,465.30

50,000

9.46%

P

2014-09-29

2014-10-01 19:56:05

officer (VP Finance and Controller)

10,738

$6.10

$65,465.30

60,738

-9.46%

S

2014-08-27

2014-08-29 16:59:05

director

10,000

$6.50

$65,000.00

11,933

0.00%

S

2014-08-27

2014-08-29 16:59:05

officer (VP, Patient Advocacy)

5,000

$7.00

$35,000.00

50,000

7.14%

P

2014-08-27

2014-08-29 16:59:05

director

10,000

$6.50

$65,000.00

21,933

0.00%

P

2014-08-27

2014-08-29 16:59:05

officer (VP, Patient Advocacy)

5,000

$7.00

$35,000.00

55,000

-7.14%

S

2014-08-25

2014-08-26 16:44:04

officer (Chief Operating Officer)

7,000

$6.00

$42,000.00

200,000

-4.00%

P

2014-08-25

2014-08-26 16:44:04

COO

7,000

$6.00

$42,000.00

207,000

4.00%

S

2014-08-25

2014-08-26 16:35:08

officer (VP, Pharmacology & Biology)

12,450

$6.00

$74,700.00

51,708

-4.00%

P

2014-08-25

2014-08-26 16:35:08

officer (VP, Pharmacology & Biology)

5,000

$6.00

$30,000.00

64,158

4.00%

P

2014-08-25

2014-08-26 16:35:08

officer (VP, Pharmacology & Biology)

7,450

$6.00

$44,700.00

59,158

4.00%

S

2014-08-25

2014-08-26 16:34:25

officer (VP, Patient Advocacy)

5,000

$6.00

$30,000.00

50,000

-4.00%

P

2014-08-25

2014-08-26 16:34:25

officer (VP, Patient Advocacy)

5,000

$6.00

$30,000.00

55,000

4.00%

S

2014-08-25

2014-08-26 16:34:01

officer (VP, Technical Operations)

7,000

$6.00

$42,000.00

50,000

-4.00%

P

2014-08-25

2014-08-26 16:34:01

officer (VP, Technical Operations)

7,000

$6.00

$42,000.00

57,000

4.00%

S

2014-08-20

2014-08-21 17:29:04

officer (VP, Patient Advocacy)

6,080

$5.40

$32,832.00

50,000

-22.41%

S

2014-08-20

2014-08-21 17:29:04

officer (VP, Technical Operations)

12,810

$5.40

$69,174.00

50,000

-22.41%

P

2014-08-20

2014-08-21 17:29:04

officer (VP, Patient Advocacy)

6,080

$5.40

$32,832.00

56,080

22.41%

P

2014-08-20

2014-08-21 17:29:04

officer (VP, Technical Operations)

7,810

$5.40

$42,174.00

62,810

22.41%

P

2014-08-20

2014-08-21 17:29:04

officer (VP, Technical Operations)

5,000

$5.40

$27,000.00

55,000

22.41%

S

2014-08-20

2014-08-21 17:15:04

officer (VP, Pharmacology & Biology)

7,000

$5.40

$37,800.00

51,708

-22.41%

P

2014-08-20

2014-08-21 17:15:04

officer (VP, Pharmacology & Biology)

7,000

$5.40

$37,800.00

58,708

22.41%

S

2014-08-20

2014-08-21 17:13:04

officer (Chief Operating Officer)

18,750

$5.40

$101,250.00

200,000

-22.41%

P

2014-08-20

2014-08-21 17:13:04

COO

18,750

$5.40

$101,250.00

218,750

22.41%

P

2014-06-30

2014-07-01 10:59:02

various various 10% owner

530,000

$3.50

$1,855,000.00

1.23394E7

28.00%

P

2014-06-30

2014-07-01 10:59:02

various various 10% owner

3,470,000

$3.50

$1.2145E7

1.18094E7

28.00%

P*

2013-11-20

2013-11-22 12:00:25

GLAXOSMITHKLINE PLC

10% owner

1,500,000

$2.00

$3,000,000.00

1.13158E7

4.50%

P

2013-03-15

2013-03-18 14:37:59

BARER SOL J

director

25,000

$3.40

$85,000.00

45,000

-11.76%

P

2012-11-13

2012-11-14 11:30:22

Winterbottom Joan

officer (SVP, Human Resources)

1,665

$4.54

$7,559.10

1,665

20.70%

P

2012-07-17

2012-07-17 17:18:12

GLAXOSMITHKLINE PLC

10% owner

2,949,580

$6.30

$1.85824E7

9,815,820

-15.87%

P

2012-03-07

2012-03-09 15:55:51

SANDELL SCOTT D

various various various various various various 1

925,154

$5.70

$5,273,380.00

4,584,310

-9.82%

P

2012-03-07

2012-03-09 15:55:10

BARRIS PETER J

10% owner

925,154

$5.70

$5,273,380.00

4,584,310

-9.82%

P

2012-03-07

2012-03-09 15:55:10

BARRIS PETER J

10% owner

214,846

$5.70

$1,224,620.00

1,066,030

-9.82%

P

2012-03-07

2012-03-09 15:54:05

KRAMLICH C RICHARD

10% owner

925,154

$5.70

$5,273,380.00

4,584,310

-9.82%

P

2012-03-07

2012-03-09 15:54:05

KRAMLICH C RICHARD

10% owner

214,846

$5.70

$1,224,620.00

1,066,030

-9.82%

P

2012-03-07

2012-03-09 15:53:55

NEWHALL CHARLES W III

10% owner

925,154

$5.70

$5,273,380.00

4,584,310

-9.82%

P

2012-03-07

2012-03-09 15:53:55

NEWHALL CHARLES W III

10% owner

214,846

$5.70

$1,224,620.00

1,066,030

-9.82%

P

2012-03-07

2012-03-09 15:53:29

PERRY MARK W

10% owner

925,154

$5.70

$5,273,380.00

4,584,310

-9.82%

P

2012-03-07

2012-03-09 15:53:29

PERRY MARK W

10% owner

214,846

$5.70

$1,224,620.00

1,066,030

-9.82%

P

2012-03-07

2012-03-09 15:52:57

BARRETT M JAMES

director 10% owner

925,154

$5.70

$5,273,380.00

4,584,310

-9.82%

P

2011-08-11

2011-08-15 12:49:53

CEO

10,000

$4.20

$42,000.00

109,867

-9.76%

P

2011-06-17

2011-06-21 10:58:33

director officer (Executive Chairman)

20,000

$6.04

$120,800.00

99,867

24.17%

S

2011-05-24

2011-05-25 15:18:46

officer (VP, Pharmacology & Biology)

2,250

$7.50

$16,875.00

1,708

23.87%

P*

2010-03-02

2010-03-03 16:09:10

CEO

11,898

$3.69

$43,903.60

71,634

-11.11%

P

2009-11-04

2009-11-05 14:21:30

BARER SOL J

director

20,000

$4.13

$82,600.00

20,000

-3.63%

S

2009-07-16

2009-07-16 17:12:32

director officer (President & CEO)

3,500

$10.29

$36,001.00

69,736

3.95%

S

2009-07-15

2009-07-16 17:12:32

director officer (President & CEO)

6,500

$10.69

$69,472.00

73,236

7.56%

S

2009-07-14

2009-07-16 17:12:32

director officer (President & CEO)

4,748

$10.28

$48,818.90

79,736

3.91%

S

2009-07-13

2009-07-13 17:09:01

director officer (President & CEO)

800

$10.09

$8,068.80

84,484

0.36%

S

2009-07-10

2009-07-13 17:09:01

director officer (President & CEO)

200

$10.06

$2,011.00

85,284

-2.34%

S

2009-07-09

2009-07-13 17:09:01

director officer (President & CEO)

1,652

$10.24

$16,918.10

85,484

-1.65%

S

2009-07-08

2009-07-08 17:12:41

director officer (President & CEO)

100

$12.49

$1,249.00

87,136

16.65%

S

2009-07-08

2009-07-08 17:12:41

director officer (President & CEO)

971

$11.09

$10,766.40

87,236

6.11%

S

2009-07-08

2009-07-08 17:12:41

director officer (President & CEO)

11,829

$10.37

$122,667.00

88,207

-0.39%

S

2009-07-07

2009-07-08 17:12:41

director officer (President & CEO)

412

$11.69

$4,814.22

100,036

10.91%

S

2009-07-07

2009-07-08 17:12:41

director officer (President & CEO)

5,788

$11.15

$64,524.60

100,448

6.62%

S

2009-07-06

2009-07-08 17:12:41

director officer (President & CEO)

10,400

$11.59

$120,494.00

106,236

13.08%

S

2009-07-06

2009-07-08 17:12:41

director officer (President & CEO)

3,100

$10.42

$32,308.20

116,636

3.38%

S

2009-06-29

2009-06-30 12:55:19

officer (Sr VP, Technical Operations)

2,500

$10.54

$26,347.50

34,040

-3.52%

S

2009-06-26

2009-06-30 12:55:19

officer (Sr VP, Technical Operations)

7,498

$10.00

$74,980.00

36,540

-10.70%

S

2009-03-30

2009-04-01 14:02:52

officer (Sr VP, Technical Operations)

2

$10.00

$20.00

44,038

10.50%

S

2009-03-25

2009-03-26 13:07:44

officer (Sr VP, Technical Operations)

531

$10.00

$5,310.00

44,040

10.20%

S

2009-03-23

2009-03-25 11:48:26

officer (Sr VP, Technical Operations)

1,740

$10.00

$17,400.00

44,571

12.20%

S

2009-03-19

2009-03-20 12:08:54

officer (Sr VP, Technical Operations)

229

$10.00

$2,290.00

46,311

8.30%

S

2009-02-11

2009-02-12 13:31:00

director

69

$9.42

$650.12

61,700

19.23%

S

2009-02-11

2009-02-12 13:31:00

director

1,839

$9.42

$17,327.10

1,652,390

19.23%

S

2009-02-03

2009-02-05 12:31:01

officer (Senior VP, Technical Operation)

7,500

$10.00

$75,000.00

46,540

19.00%

S

2008-12-08

2008-12-10 15:12:24

director

108

$8.54

$922.10

61,769

6.18%

S

2008-12-08

2008-12-10 15:12:24

director

2,892

$8.54

$24,691.90

1,654,230

6.18%

S

2008-12-03

2008-12-05 15:07:55

director

1

$8.50

61,877

5.88%

S

2008-12-03

2008-12-05 15:07:55

director

24

$8.50

$204.00

1,657,120

5.88%

S

2008-12-02

2008-12-03 15:20:37

director

56

$8.50

$476.00

61,878

5.88%

S

2008-12-02

2008-12-03 15:20:37

director

1,488

$8.50

$12,648.00

1,657,140

5.88%

S*

2008-12-01

2008-12-03 15:20:37

director

4

$8.90

$35.60

1,658,630

10.34%

S

2008-11-28

2008-12-01 15:16:26

director

108

$8.50

$918.00

61,934

6.12%

S

2008-11-28

2008-12-01 15:16:26

director

2,892

$8.50

$24,582.00

1,658,640

6.12%

S

2008-11-26

2008-12-01 15:16:26

director

108

$8.52

$919.84

62,042

6.31%

S

2008-11-26

2008-12-01 15:16:26

director

2,892

$8.52

$24,631.20

1,661,530

6.31%

S

2008-11-24

2008-11-26 10:44:17

director

108

$8.52

$920.05

62,150

6.09%

S

2008-11-24

2008-11-26 10:44:17

director

2,892

$8.52

$24,636.90

1,664,420

6.09%

S

2008-11-21

2008-11-24 14:20:55

director

88

$8.50

$748.00

62,258

7.06%

S

2008-11-21

2008-11-24 14:20:55

director

2,348

$8.50

$19,958.00

1,667,310

7.06%

S

2008-11-20

2008-11-24 14:20:55

director

108

$8.83

$954.07

62,346

10.57%

S

2008-11-20

2008-11-24 14:20:55

director

2,892

$8.83

$25,547.90

1,669,660

10.57%

S

2008-11-19

2008-11-20 15:01:42

director

108

$9.03

$975.46

62,454

12.53%

S

2008-11-19

2008-11-20 15:01:42

director

2,892

$9.03

$26,120.50

1,672,550

12.53%

S

2008-11-18

2008-11-20 15:01:42

director

108

$9.11

$983.66

62,562

17.65%

S

2008-11-18

2008-11-20 15:01:42

director

2,892

$9.11

$26,340.30

1,675,440

17.65%

S

2008-11-17

2008-11-18 15:00:37

director

279

$9.02

$2,517.14

62,670

12.44%

S

2008-11-17

2008-11-18 15:00:37

director

7,461

$9.02

$67,313.10

1,678,340

12.44%

S

2008-11-14

2008-11-18 15:00:37

director

137

$9.34

$1,279.85

62,949

15.33%

S

2008-11-14

2008-11-18 15:00:37

director

3,663

$9.34

$34,219.70

1,685,800

15.33%

S

2008-11-13

2008-11-14 14:53:50

director

108

$9.41

$1,015.85

63,086

15.90%

S

2008-11-13

2008-11-14 14:53:50

director

2,892

$9.41

$27,202.20

1,689,460

15.90%

S

2008-11-12

2008-11-14 14:53:50

director

108

$9.58

$1,034.64

63,194

17.43%

S

2008-11-12

2008-11-14 14:53:50

director

2,892

$9.58

$27,705.40

1,692,350

17.43%

S

2008-11-11

2008-11-12 15:17:51

director

108

$9.20

$993.49

63,302

16.84%

S

2008-11-11

2008-11-12 15:17:51

director

2,892

$9.20

$26,603.50

1,695,240

16.84%

S

2008-11-10

2008-11-12 15:17:51

director

108

$8.98

$969.73

63,410

10.01%

S

2008-11-10

2008-11-12 15:17:51

director

2,892

$8.98

$25,967.30

1,698,140

10.01%

S

2008-11-07

2008-11-10 14:38:57

director

108

$9.08

$980.64

63,518

11.34%

S

2008-11-07

2008-11-10 14:38:57

director

2,892

$9.08

$26,259.40

1,701,030

11.34%

S

2008-11-06

2008-11-10 14:38:57

director

108

$9.24

$998.35

63,626

12.92%

S

2008-11-06

2008-11-10 14:38:57

director

2,892

$9.24

$26,733.60

1,703,920

12.92%

S

2008-11-05

2008-11-06 15:17:37

director

140

$10.04

$1,405.88

63,734

19.84%

S

2008-11-05

2008-11-06 15:17:37

director

3,760

$10.04

$37,757.90

1,706,810

19.84%

S

2008-11-04

2008-11-06 15:17:37

director

137

$10.54

$1,444.53

63,874

23.65%

S

2008-11-04

2008-11-06 15:17:37

director

3,663

$10.54

$38,622.70

1,710,570

23.65%

S

2008-11-03

2008-11-04 15:55:20

director officer (President & CEO)

5,000

$10.29

$51,450.00

5,200

22.45%

S

2008-11-03

2008-11-04 15:55:20

director officer (President & CEO)

5,000

$10.27

$51,335.00

18,033

22.28%

S

2008-11-03

2008-11-04 15:41:28

director

108

$10.24

$1,105.92

64,011

22.07%

S

2008-11-03

2008-11-04 15:41:28

director

2,892

$10.24

$29,614.10

1,714,240

22.07%

S

2008-10-31

2008-11-04 15:41:28

director

108

$9.85

$1,063.80

64,119

9.64%

S

2008-10-31

2008-11-04 15:41:28

director

2,892

$9.85

$28,486.20

1,717,130

9.64%

S

2008-10-31

2008-11-03 15:05:50

officer (Senior VP, Drug Development)

2,200

$10.00

$22,000.00

49,116

11.00%

S

2008-10-30

2008-11-03 15:05:50

officer (Senior VP, Drug Development)

300

$10.00

$3,000.00

51,316

11.00%

S

2008-10-31

2008-11-03 15:03:28

officer (Chief Operating Officer)

1,939

$10.00

$19,390.00

36,449

11.00%

S

2008-10-30

2008-11-03 15:03:28

officer (Chief Operating Officer)

361

$10.00

$3,610.00

38,388

11.00%

S

2008-10-30

2008-10-31 14:19:45

director

108

$9.54

$1,030.54

64,227

6.73%

S

2008-10-30

2008-10-31 14:19:45

director

2,892

$9.54

$27,595.50

1,720,020

6.73%

S

2008-10-29

2008-10-31 14:19:45

director

108

$8.51

$919.40

64,335

-4.55%

S

2008-10-29

2008-10-31 14:19:45

director

2,892

$8.51

$24,619.60

1,722,910

-4.55%

S

2008-10-28

2008-10-29 15:07:41

director

94

$8.50

$799.00

64,443

-4.71%

S

2008-10-28

2008-10-29 15:07:41

director

2,507

$8.50

$21,309.50

1,725,800

-4.71%

S

2008-10-27

2008-10-29 15:07:41

director

106

$8.89

$941.81

64,537

-1.18%

S

2008-10-27

2008-10-29 15:07:41

director

2,836

$8.89

$25,197.90

1,728,310

-1.18%

S

2008-10-24

2008-10-27 16:08:13

director

108

$9.70

$1,047.49

64,643

7.21%

S

2008-10-24

2008-10-27 16:08:13

director

2,892

$9.70

$28,049.50

1,731,150

7.21%

S

2008-10-23

2008-10-27 16:08:13

director

108

$9.76

$1,053.54

64,751

13.28%

S

2008-10-23

2008-10-27 16:08:13

director

2,892

$9.76

$28,211.50

1,734,040

13.28%

S

2008-10-23

2008-10-24 15:28:00

officer (Chief Operating Officer)

100

$10.10

$1,010.00

38,749

16.24%

S

2008-10-22

2008-10-24 15:28:00

officer (Chief Operating Officer)

3,100

$10.40

$32,246.20

38,849

18.67%

S

2008-10-22

2008-10-23 16:08:39

director

108

$10.48

$1,131.30

64,859

19.24%

S

2008-10-22

2008-10-23 16:08:39

director

2,892

$10.48

$30,293.70

1,736,930

19.24%

S

2008-10-21

2008-10-23 16:08:39

director

108

$10.51

$1,135.40

64,967

19.53%

S

2008-10-21

2008-10-23 16:08:39

director

2,892

$10.51

$30,403.60

1,739,820

19.53%

S

2008-10-21

2008-10-22 15:47:48

officer (Chief Operating Officer)

2,500

$10.51

$26,262.50

41,949

19.47%

S

2008-10-20

2008-10-22 15:47:48

officer (Chief Operating Officer)

100

$11.51

$1,151.00

44,449

28.32%

S

2008-10-20

2008-10-22 15:47:48

officer (Chief Operating Officer)

1,900

$10.73

$20,392.70

44,549

23.13%

S

2008-10-20

2008-10-21 15:40:11

director

108

$10.59

$1,143.40

65,075

22.07%

S

2008-10-20

2008-10-21 15:40:11

director

2,892

$10.59

$30,617.60

1,742,720

22.07%

S

2008-10-17

2008-10-21 15:40:11

director

108

$10.75

$1,160.89

65,183

14.97%

S

2008-10-17

2008-10-21 15:40:11

director

2,892

$10.75

$31,086.10

1,745,610

14.97%

S

2008-10-16

2008-10-17 15:18:23

director

108

$10.51

$1,135.30

65,291

13.91%

S

2008-10-16

2008-10-17 15:18:23

director

2,892

$10.51

$30,400.70

1,748,500

13.91%

S

2008-10-15

2008-10-17 15:18:23

director

94

$10.55

$991.42

65,399

14.19%

S

2008-10-15

2008-10-17 15:18:23

director

14

$11.50

$161.00

65,493

21.30%

S

2008-10-15

2008-10-17 15:18:23

director

2,507

$10.54

$26,428.80

1,751,390

14.15%

S

2008-10-15

2008-10-17 15:18:23

director

385

$11.50

$4,427.50

1,753,900

21.30%

S

2008-10-14

2008-10-15 13:35:42

director

108

$12.41

$1,339.85

65,507

27.05%

S

2008-10-14

2008-10-15 13:35:42

director

2,892

$12.41

$35,878.20

1,754,280

27.05%

S

2008-10-13

2008-10-15 13:35:42

director

105

$12.58

$1,321.11

65,615

21.32%

S*

2008-10-13

2008-10-15 13:35:42

director

3

$13.75

$41.25

65,720

28.00%

S

2008-10-13

2008-10-15 13:35:42

director

2,827

$12.59

$35,586.30

1,757,180

21.35%

S*

2008-10-13

2008-10-15 13:35:42

director

65

$13.75

$893.75

1,760,000

28.00%

S

2008-10-06

2008-10-07 14:14:03

director officer (President & CEO)

1,200

$14.76

$17,708.40

10,200

38.74%

S

2008-10-06

2008-10-07 14:14:03

director officer (President & CEO)

1,100

$14.75

$16,228.30

23,033

38.72%

S

2008-10-03

2008-10-07 14:14:03

director officer (President & CEO)

1,900

$14.98

$28,452.50

11,400

30.22%

S

2008-10-03

2008-10-07 14:14:03

director officer (President & CEO)

1,800

$14.96

$26,928.00

24,133

30.15%

S

2008-10-02

2008-10-03 11:51:18

director officer (President & CEO)

1,300

$15.06

$19,581.90

13,300

29.43%

S

2008-10-02

2008-10-03 11:51:18

director officer (President & CEO)

1,300

$15.13

$19,669.00

25,933

29.74%

S

2008-10-01

2008-10-03 11:51:18

director officer (President & CEO)

600

$15.08

$9,049.80

14,600

29.52%

S

2008-10-01

2008-10-03 11:51:18

director officer (President & CEO)

800

$15.08

$12,063.20

27,233

29.50%

S

2008-09-29

2008-09-30 10:38:00

officer (Senior VP, Drug Development)

200

$16.22

$3,244.96

51,616

38.98%

S

2008-09-29

2008-09-30 10:38:00

officer (Senior VP, Drug Development)

2,300

$15.03

$34,558.20

51,816

34.11%

S

2008-09-22

2008-09-23 17:00:52

director

103

$16.02

$1,649.75

65,723

37.57%

S

2008-09-22

2008-09-23 17:00:52

director

2,726

$16.02

$43,662.30

1,760,070

37.57%

S

2008-09-19

2008-09-23 17:00:52

director

182

$15.77

$2,870.87

65,826

33.43%

S

2008-09-19

2008-09-23 17:00:52

director

219

$17.07

$3,737.24

66,008

38.47%

S

2008-09-19

2008-09-23 17:00:52

director

4,858

$15.77

$76,630.10

1,762,790

33.43%

S

2008-09-19

2008-09-23 17:00:52

director

5,870

$17.06

$100,160.00

1,767,650

38.46%

S

2008-09-18

2008-09-19 19:41:14

director

108

$14.02

$1,514.59

66,227

25.13%

S

2008-09-18

2008-09-19 19:41:14

director

11

$16.00

$176.04

66,335

34.39%

S

2008-09-18

2008-09-19 19:41:14

director

2,892

$14.03

$40,563.20

1,773,520

25.14%

S

2008-09-18

2008-09-19 19:41:14

director

289

$16.01

$4,628.05

1,776,410

34.43%

S

2008-09-17

2008-09-19 19:41:14

director

108

$14.13

$1,525.93

66,346

25.68%

S

2008-09-17

2008-09-19 19:41:14

director

2,892

$14.13

$40,861.10

1,776,700

25.68%

S

2008-09-16

2008-09-17 15:59:28

director

108

$14.13

$1,525.61

66,454

22.13%

S

2008-09-16

2008-09-17 15:59:28

director

2,892

$14.13

$40,852.40

1,779,590

22.13%

S

2008-09-15

2008-09-17 15:59:28

director

158

$14.07

$2,223.22

66,562

25.38%

S

2008-09-15

2008-09-17 15:59:28

director

4,242

$14.07

$59,689.20

1,782,490

25.38%

S

2008-09-12

2008-09-15 16:26:09

director

108

$14.09

$1,522.04

66,720

11.30%

S

2008-09-12

2008-09-15 16:26:09

director

2,892

$14.09

$40,757.00

1,786,730

11.30%

S

2008-09-11

2008-09-15 16:26:09

director

108

$14.71

$1,588.79

66,828

15.03%

S

2008-09-11

2008-09-15 16:26:09

director

2,892

$14.71

$42,544.20

1,789,620

15.03%

S

2008-09-10

2008-09-11 18:20:55

director

108

$13.77

$1,487.70

66,936

9.26%

S

2008-09-10

2008-09-11 18:20:55

director

2,892

$13.77

$39,837.30

1,792,510

9.26%

S

2008-09-09

2008-09-11 18:20:55

director

205

$13.79

$2,826.75

67,044

23.85%

S

2008-09-09

2008-09-11 18:20:55

director

5,495

$13.79

$75,770.60

1,795,400

23.85%

S

2008-09-08

2008-09-10 15:56:17

officer (Senior VP, Drug Development)

3,000

$14.83

$44,496.00

54,116

19.57%

S

2008-09-08

2008-09-09 20:07:45

director

108

$14.91

$1,610.39

67,249

19.99%

S

2008-09-08

2008-09-09 20:07:45

director

2,892

$14.91

$43,122.60

1,800,900

19.99%

S

2008-09-05

2008-09-09 20:07:45

director

108

$13.75

$1,485.00

67,357

-8.36%

S

2008-09-05

2008-09-09 20:07:45

director

2,892

$13.75

$39,765.00

1,803,790

-8.36%

S

2008-09-05

2008-09-08 19:16:17

director officer (President and CEO)

1,200

$13.74

$16,490.40

15,200

-8.43%

S

2008-09-05

2008-09-08 19:16:17

director officer (President and CEO)

1,300

$13.74

$17,865.90

28,033

-8.42%

S

2008-09-04

2008-09-08 19:16:17

director officer (President and CEO)

1,300

$13.85

$17,998.50

16,400

-7.62%

S

2008-09-04

2008-09-08 19:16:17

director officer (President and CEO)

1,200

$13.83

$16,600.80

29,333

-7.71%

S

2008-09-04

2008-09-05 18:05:46

director

108

$13.76

$1,485.76

67,465

-8.31%

S

2008-09-04

2008-09-05 18:05:46

director

2,892

$13.76

$39,785.20

1,806,680

-8.31%

S

2008-09-03

2008-09-05 18:05:46

director

108

$13.72

$1,482.19

67,573

-8.57%

S

2008-09-03

2008-09-05 18:05:46

director

2,892

$13.72

$39,689.80

1,809,580

-8.57%

S

2008-09-03

2008-09-04 17:16:59

director officer (President & CEO)

1,200

$13.78

$16,542.00

17,700

-8.09%

S

2008-09-03

2008-09-04 17:16:59

director officer (President & CEO)

1,300

$13.74

$17,868.50

30,533

-8.40%

S

2008-09-02

2008-09-04 17:16:59

director officer (President & CEO)

1,300

$13.82

$17,967.30

18,900

-8.60%

S

2008-09-02

2008-09-04 17:16:59

director officer (President & CEO)

1,300

$13.75

$17,871.10

31,833

-9.19%

S

2008-09-02

2008-09-03 19:04:53

director

108

$13.81

$1,491.70

67,681

-8.67%

S

2008-09-02

2008-09-03 19:04:53

director

2,892

$13.81

$39,944.30

1,812,470

-8.67%

S

2008-08-29

2008-09-03 19:04:53

director

108

$13.79

$1,489.64

67,789

-9.11%

S

2008-08-29

2008-09-03 19:04:53

director

2,892

$13.79

$39,889.40

1,815,360

-9.11%

S

2008-09-02

2008-09-03 19:03:26

director

108

$13.81

$1,491.70

67,681

-8.67%

S*

2008-09-02

2008-09-03 19:03:26

director

2,892

$13,812.00

$3.99443E7

1,812,470

99.89%

S

2008-08-29

2008-09-03 19:03:26

director

108

$13.79

$1,489.64

67,789

-9.11%

S

2008-08-29

2008-09-03 19:03:26

director

2,892

$13.79

$39,889.40

1,815,360

-9.11%

S

2008-08-28

2008-09-02 18:56:22

officer (Senior VP, Drug Development)

2,500

$13.77

$34,425.00

57,116

-10.68%

S

2008-08-28

2008-08-29 16:15:40

director

108

$13.81

$1,491.37

67,897

-10.36%

S

2008-08-28

2008-08-29 16:15:40

director

2,892

$13.81

$39,935.60

1,818,250

-10.36%

S

2008-08-27

2008-08-29 16:15:40

director

108

$13.90

$1,500.66

68,005

-9.68%

S

2008-08-27

2008-08-29 16:15:40

director

2,892

$13.90

$40,184.30

1,821,140

-9.68%

S

2008-08-26

2008-08-28 17:35:03

director officer (President and CEO)

13,333

$13.61

$181,475.00

0

-11.97%

S

2008-08-26

2008-08-27 17:12:56

director

151

$13.64

$2,059.49

68,113

-11.74%

S

2008-08-26

2008-08-27 17:12:56

director

4,049

$13.64

$55,224.30

1,824,040

-11.74%

S

2008-08-25

2008-08-27 17:12:56

director

108

$13.67

$1,476.14

68,264

-9.89%

S

2008-08-25

2008-08-27 17:12:56

director

2,892

$13.67

$39,527.90

1,828,080

-9.89%

S

2008-08-22

2008-08-25 16:05:29

director

108

$13.52

$1,460.48

68,372

-21.94%

S

2008-08-22

2008-08-25 16:05:29

director

2,892

$13.52

$39,108.50

1,830,980

-21.94%

S

2008-08-21

2008-08-25 16:05:29

director

108

$13.57

$1,465.88

68,480

-16.19%

S

2008-08-21

2008-08-25 16:05:29

director

2,892

$13.57

$39,253.10

1,833,870

-16.19%

S

2008-08-20

2008-08-21 17:28:55

director

108

$13.72

$1,481.76

68,588

N/A

S

2008-08-20

2008-08-21 17:28:55

director

2,892

$13.72

$39,678.20

1,836,760

-14.94%

S

2008-08-19

2008-08-21 17:28:55

director

108

$13.56

$1,464.16

68,696

-16.32%

S

2008-08-19

2008-08-21 17:28:55

director

2,892

$13.56

$39,206.80

1,839,650

-16.32%

S

2008-08-20

2008-08-21 17:24:38

officer (Chief Operating Officer)

2,000

$13.53

$27,070.00

46,449

-16.51%

S

2008-08-19

2008-08-20 17:13:33

officer (Chief Operating Officer)

700

$14.50

$10,149.30

48,449

-8.77%

S

2008-08-19

2008-08-20 17:13:33

officer (Chief Operating Officer)

3,800

$13.71

$52,094.20

49,149

-15.03%

S

2008-08-18

2008-08-20 17:13:33

officer (Chief Operating Officer)

800

$16.04

$12,834.40

52,949

-1.91%

S

2008-08-18

2008-08-20 17:13:33

officer (Chief Operating Officer)

2,700

$15.02

$40,554.00

53,749

-8.85%

S

2008-08-18

2008-08-20 16:19:23

Licholai Gregory P

officer (VP, Medical Affairs)

1,401

$15.11

$21,163.50

152

-8.24%

S

2008-08-18

2008-08-19 16:22:56

director

45

$14.82

$667.08

68,804

-10.29%

S

2008-08-18

2008-08-19 16:22:56

director

63

$15.45

$973.16

68,849

-5.85%

S

2008-08-18

2008-08-19 16:22:56

director

1,255

$14.84

$18,617.90

1,842,540

-10.21%

S

2008-08-18

2008-08-19 16:22:56

director

1,637

$15.46

$25,303.10

1,843,800

-5.78%

S

2008-08-15

2008-08-19 16:22:56

director

108

$16.46

$1,777.79

68,912

14.95%

S

2008-08-15

2008-08-19 16:22:56

director

2,892

$16.46

$47,605.20

1,845,440

14.95%

S

2008-08-15

2008-08-19 16:17:56

director

1,400

$16.74

$23,438.80

12,933

16.38%

S

2008-08-14

2008-08-18 16:07:39

Weinhoff Gregory M

director

3,156

$17.00

$53,652.00

129,943

16.35%

S

2008-08-14

2008-08-18 16:07:39

Weinhoff Gregory M

director

46,844

$17.00

$796,348.00

1,928,610

16.35%

S

2008-08-14

2008-08-15 16:44:43

director

362

$17.03

$6,165.58

69,020

16.51%

S

2008-08-14

2008-08-15 16:44:43

director

9,704

$17.03

$165,279.00

1,848,330

16.51%

S

2008-08-13

2008-08-15 16:44:43

director

205

$17.57

$3,602.05

69,382

19.07%

S

2008-08-13

2008-08-15 16:44:43

director

5,495

$17.57

$96,552.60

1,858,030

19.07%

S

2008-08-13

2008-08-14 17:03:51

Schaeffer Orlov S Nicole

officer (Sr. VP, HR & Lead.Devlop.)

5

$18.00

$90.00

12,582

21.00%

S

2008-08-12

2008-08-14 17:03:51

Schaeffer Orlov S Nicole

officer (Sr. VP, HR & Lead.Devlop.)

208

$18.00

$3,744.00

12,587

21.00%

S

2008-08-12

2008-08-13 16:36:47

director

120

$16.65

$1,997.64

69,587

14.58%

S

2008-08-12

2008-08-13 16:36:47

director

154

$17.28

$2,661.43

69,707

17.72%

S

2008-08-12

2008-08-13 16:36:47

director

3,280

$16.66

$54,631.70

1,863,530

14.63%

S

2008-08-12

2008-08-13 16:36:47

director

4,066

$17.28

$70,280.80

1,866,810

17.73%

S

2008-08-11

2008-08-13 16:36:47

director

108

$16.26

$1,755.97

69,861

10.20%

S

2008-08-11

2008-08-13 16:36:47

director

18

$17.37

$312.73

69,969

15.97%

S

2008-08-11

2008-08-13 16:36:47

director

2,892

$16.26

$47,021.00

1,870,870

10.20%

S

2008-08-11

2008-08-13 16:36:47

director

482

$17.38

$8,375.23

1,873,760

15.98%

S

2008-08-08

2008-08-11 16:35:04

director

108

$16.70

$1,803.28

69,987

11.72%

S

2008-08-08

2008-08-11 16:35:04

director

2,892

$16.70

$48,287.70

1,874,250

11.72%

S

2008-08-07

2008-08-11 16:35:04

director

151

$16.58

$2,503.58

70,095

16.53%

S

2008-08-07

2008-08-11 16:35:04

director

4,049

$16.58

$67,132.40

1,877,140

16.53%

S

2008-08-06

2008-08-07 16:20:48

director

109

$15.60

$1,700.73

70,246

11.30%

S

2008-08-06

2008-08-07 16:20:48

director

67

$16.76

$1,123.26

70,355

17.45%

S

2008-08-06

2008-08-07 16:20:48

director

2,891

$15.60

$45,108.30

1,881,190

11.30%

S

2008-08-06

2008-08-07 16:20:48

director

1,812

$16.75

$30,352.80

1,884,080

17.38%

S

2008-08-05

2008-08-07 16:20:48

director

108

$15.55

$1,679.83

70,422

11.02%

S

2008-08-05

2008-08-07 16:20:48

director

2,892

$15.55

$44,982.20

1,885,890

11.02%

S

2008-08-04

2008-08-05 17:12:51

director officer (President & CEO)

3,000

$15.22

$45,648.00

20,200

7.93%

S

2008-08-04

2008-08-05 17:12:51

director officer (President & CEO)

3,200

$15.27

$48,857.60

33,133

8.24%

S

2008-08-01

2008-08-05 17:12:51

director officer (President & CEO)

2,000

$15.43

$30,858.00

23,200

9.59%

S

2008-08-01

2008-08-05 17:12:51

director officer (President & CEO)

1,800

$15.41

$27,747.00

36,333

9.50%

S

2008-08-04

2008-08-05 17:09:18

director

162

$15.23

$2,467.91

70,530

8.03%

S

2008-08-04

2008-08-05 17:09:18

director

4,338

$15.23

$66,085.10

1,888,780

8.03%

S

2008-08-01

2008-08-05 17:09:18

director

133

$15.45

$2,054.98

70,692

9.71%

S

2008-08-01

2008-08-05 17:09:18

director

3,567

$15.45

$55,113.70

1,893,120

9.71%

S

2008-07-31

2008-08-01 17:16:15

director

360

$15.47

$5,567.40

70,825

9.80%

S*

2008-07-31

2008-08-01 17:16:15

director

9,640

$15,465.00

$1.49083008E8

1,896,690

99.91%

S

2008-07-30

2008-08-01 17:16:15

director

169

$15.19

$2,566.26

71,185

8.13%

S

2008-07-30

2008-08-01 17:16:15

director

4,531

$15.19

$68,803.20

1,906,330

8.13%

S

2008-07-29

2008-07-30 17:49:39

director

130

$15.30

$1,989.26

71,354

8.84%

S

2008-07-29

2008-07-30 17:49:39

director

3,470

$15.30

$53,097.90

1,910,860

8.84%

S

2008-07-28

2008-07-30 17:49:39

director

324

$15.23

$4,932.90

71,484

7.06%

S

2008-07-28

2008-07-30 17:49:39

director

8,676

$15.23

$132,092.00

1,914,330

7.06%

S

2008-07-28

2008-07-30 17:47:58

officer (Senior VP, Drug Development)

2,500

$15.08

$37,692.50

59,616

6.15%

S

2008-07-25

2008-07-28 16:17:33

director

83

$15.43

$1,280.86

71,808

9.80%

S

2008-07-25

2008-07-28 16:17:33

director

2,217

$15.43

$34,212.70

1,923,000

9.80%

S

2008-07-24

2008-07-28 16:17:33

director

204

$15.23

$3,107.94

71,891

9.09%

S

2008-07-24

2008-07-28 16:17:33

director

5,457

$15.23

$83,137.40

1,925,220

9.09%

S

2008-07-23

2008-07-24 16:50:00

director

66

$15.00

$989.87

72,095

10.05%

S

2008-07-23

2008-07-24 16:50:00

director

1,768

$15.00

$26,516.50

1,930,680

10.05%

S

2008-07-22

2008-07-24 16:50:00

director

309

$15.01

$4,636.54

72,161

10.10%

S

2008-07-22

2008-07-24 16:50:00

director

8,280

$15.01

$124,241.00

1,932,450

10.10%

S

2008-07-22

2008-07-23 17:19:07

Licholai Gregory P

officer (VP, Medical Affairs)

15,000

$15.00

$225,000.00

152

10.07%

S

2008-07-21

2008-07-22 16:56:38

director

274

$14.47

$3,964.78

72,470

6.77%

S

2008-07-21

2008-07-22 16:56:38

director

7,326

$14.47

$106,007.00

1,940,730

6.77%

S

2008-07-18

2008-07-22 16:56:38

director

374

$13.86

$5,182.89

72,744

-8.39%

S

2008-07-18

2008-07-22 16:56:38

director

10,026

$13.86

$138,940.00

1,948,050

-8.39%

S

2008-06-19

2008-07-22 16:23:00

officer (Chief Operating Officer)

14

$11.11

$155.54

57,849

-26.55%

S

2008-06-19

2008-07-22 16:23:00

officer (Chief Operating Officer)

300

$11.03

$3,309.00

57,863

-27.47%

S

2008-06-19

2008-07-22 16:23:00

officer (Chief Operating Officer)

86

$11.02

$947.72

58,163

-27.59%

S

2008-06-18

2008-07-22 16:23:00

officer (Chief Operating Officer)

100

$11.12

$1,112.00

58,249

-26.44%

S

2008-06-18

2008-07-22 16:23:00

officer (Chief Operating Officer)

200

$11.02

$2,204.00

58,349

-27.59%

S

2008-06-18

2008-07-22 16:23:00

officer (Chief Operating Officer)

200

$11.01

$2,202.00

58,549

-27.70%

S

2008-06-18

2008-07-22 16:23:00

officer (Chief Operating Officer)

400

$11.00

$4,400.00

58,749

-27.82%

S

2008-06-18

2008-07-22 16:23:00

officer (Chief Operating Officer)

100

$10.99

$1,099.00

59,149

-27.93%

S

2008-06-18

2008-07-22 16:23:00

officer (Chief Operating Officer)

400

$10.97

$4,388.00

59,249

-28.17%

S

2008-06-18

2008-07-22 16:23:00

officer (Chief Operating Officer)

100

$10.95

$1,095.00

59,649

-28.40%

S

2008-06-20

2008-07-22 16:22:54

officer (Chief Operating Officer)

400

$11.54

$4,616.00

56,449

-21.84%

S

2008-06-20

2008-07-22 16:22:54

officer (Chief Operating Officer)

200

$11.50

$2,300.00

56,849

-22.26%

S

2008-06-20

2008-07-22 16:22:54

officer (Chief Operating Officer)

400

$11.35

$4,540.00

57,049

-23.88%

S

2008-06-20

2008-07-22 16:22:54

officer (Chief Operating Officer)

123

$11.26

$1,384.98

57,449

-24.87%

S

2008-06-20

2008-07-22 16:22:54

officer (Chief Operating Officer)

277

$11.25

$3,116.25

57,572

-24.98%

S

2008-07-17

2008-07-18 16:29:06

director

58

$13.38

$775.81

73,118

-22.38%

S

2008-07-17

2008-07-18 16:29:06

director

1,542

$13.38

$20,625.80

1,958,080

-22.38%

S

2008-07-16

2008-07-18 16:29:06

director

68

$13.16

$895.02

73,176

-24.37%

S

2008-07-16

2008-07-18 16:29:06

director

1,832

$13.16

$24,112.80

1,959,620

-24.37%

S

2008-07-15

2008-07-17 16:40:54

Licholai Gregory P

officer (VP, Medical Affairs)

15,000

$13.00

$195,000.00

152

-25.92%

S

2008-07-15

2008-07-16 17:54:03

director

202

$12.90

$2,604.79

73,244

-26.95%

S

2008-07-15

2008-07-16 17:54:03

director

5,398

$12.90

$69,607.20

1,961,450

-26.95%

S

2008-07-14

2008-07-16 17:54:03

director

57

$12.61

$718.60

73,446

-34.05%

S

2008-07-14

2008-07-16 17:54:03

director

1,543

$12.61

$19,452.60

1,966,850

-34.05%

S

2008-07-11

2008-07-16 17:54:03

director

320

$12.55

$4,016.00

73,503

-39.20%

S

2008-07-11

2008-07-16 17:54:03

director

8,573

$12.55

$107,591.00

1,968,390

-39.20%

S

2008-07-07

2008-07-08 17:04:16

director officer (President and CEO)

300

$11.24

$3,372.00

25,200

-44.84%

S

2008-07-07

2008-07-08 17:04:16

director officer (President and CEO)

400

$11.22

$4,488.00

25,500

-45.10%

S

2008-07-07

2008-07-08 17:04:16

director officer (President and CEO)

135

$11.16

$1,506.60

25,900

-45.88%

S

2008-07-07

2008-07-08 17:04:16

director officer (President and CEO)

65

$11.15

$724.75

26,035

-46.01%

S

2008-07-07

2008-07-08 17:04:16

director officer (President and CEO)

100

$10.70

$1,070.00

26,100

-52.15%

S

2008-07-07

2008-07-08 17:04:16

director officer (President and CEO)

200

$11.26

$2,252.00

38,133

-44.58%

S

2008-07-07

2008-07-08 17:04:16

director officer (President and CEO)

208

$11.24

$2,337.92

38,333

-44.84%

S

2008-07-07

2008-07-08 17:04:16

director officer (President and CEO)

100

$11.23

$1,123.00

38,541

-44.97%

S

2008-07-07

2008-07-08 17:04:16

director officer (President and CEO)

300

$11.22

$3,366.00

38,641

-45.10%

S

2008-07-07

2008-07-08 17:04:16

director officer (President and CEO)

92

$11.19

$1,029.48

38,941

-45.49%

S

2008-07-07

2008-07-08 17:04:16

director officer (President and CEO)

200

$10.75

$2,150.00

39,033

-51.44%

S

2008-07-07

2008-07-08 17:04:16

director officer (President and CEO)

100

$10.69

$1,069.00

39,233

-52.29%

S

2008-07-03

2008-07-08 17:04:16

director officer (President and CEO)

200

$11.03

$2,206.00

26,200

-41.52%

S

2008-07-03

2008-07-08 17:04:16

director officer (President and CEO)

100

$10.89

$1,089.00

26,400

-43.34%

S

2008-07-03

2008-07-08 17:04:16

director officer (President and CEO)

300

$10.75

$3,225.00

26,500

-45.21%

S

2008-07-03

2008-07-08 17:04:16

director officer (President and CEO)

100

$10.73

$1,073.00

26,800

-45.48%

S

2008-07-03

2008-07-08 17:04:16

director officer (President and CEO)

200

$11.03

$2,206.00

39,333

-41.52%

S

2008-07-03

2008-07-08 17:04:16

director officer (President and CEO)

400

$10.75

$4,300.00

39,533

-45.21%

S

2008-07-03

2008-07-08 17:04:16

director officer (President and CEO)

200

$10.73

$2,146.00

39,933

-45.48%

S

2008-07-02

2008-07-03 13:43:56

director officer (President and CEO)

700

$11.11

$7,777.00

26,900

-40.50%

S

2008-07-02

2008-07-03 13:43:56

director officer (President and CEO)

209

$11.09

$2,317.81

27,600

-40.76%

S

2008-07-02

2008-07-03 13:43:56

director officer (President and CEO)

200

$11.08

$2,216.00

27,809

-40.88%

S

2008-07-02

2008-07-03 13:43:56

director officer (President and CEO)

100

$11.06

$1,106.00

28,009

-41.14%

S

2008-07-02

2008-07-03 13:43:56

director officer (President and CEO)

91

$11.04

$1,004.64

28,109

-41.39%

S

2008-07-02

2008-07-03 13:43:56

director officer (President and CEO)

100

$10.92

$1,092.00

28,200

-42.95%

S

2008-07-01

2008-07-03 13:43:56

director officer (President and CEO)

23

$10.79

$248.17

28,300

-44.67%

S

2008-07-01

2008-07-03 13:43:56

director officer (President and CEO)

600

$10.78

$6,468.00

28,323

-44.81%

S

2008-07-01

2008-07-03 13:43:56

director officer (President and CEO)

100

$10.76

$1,076.00

28,923

-45.07%

S

2008-07-01

2008-07-03 13:43:56

director officer (President and CEO)

100

$10.75

$1,075.00

29,023

-45.21%

S

2008-07-01

2008-07-03 13:43:56

director officer (President and CEO)

300

$10.73

$3,219.00

29,123

-45.48%

S

2008-07-01

2008-07-03 13:43:56

director officer (President and CEO)

477

$10.72

$5,113.44

29,423

-45.62%

S

2008-07-01

2008-07-03 13:43:56

director officer (President and CEO)

100

$10.63

$1,063.00

29,900

-46.85%

S

2008-07-02

2008-07-03 13:43:56

director officer (President and CEO)

200

$11.13

$2,226.00

40,133

-40.25%

S

2008-07-02

2008-07-03 13:43:56

director officer (President and CEO)

600

$11.11

$6,666.00

40,333

-40.50%

S

2008-07-02

2008-07-03 13:43:56

director officer (President and CEO)

200

$11.08

$2,216.00

40,933

-40.88%

S

2008-07-02

2008-07-03 13:43:56

director officer (President and CEO)

400

$11.06

$4,424.00

41,133

-41.14%

S

2008-07-02

2008-07-03 13:43:56

director officer (President and CEO)

100

$11.00

$1,100.00

41,533

-41.91%

S

2008-07-02

2008-07-03 13:43:56

director officer (President and CEO)

100

$10.92

$1,092.00

41,633

-42.95%

S

2008-07-01

2008-07-03 13:43:56

director officer (President and CEO)

500

$10.76

$5,380.00

41,733

-45.07%

S

2008-07-01

2008-07-03 13:43:56

director officer (President and CEO)

800

$10.72

$8,576.00

42,233

-45.62%

S

2008-07-01

2008-07-03 13:43:56

director officer (President and CEO)

200

$10.70

$2,140.00

43,033

-45.89%

S

2008-07-01

2008-07-03 13:43:56

director officer (President and CEO)

100

$10.62

$1,062.00

43,233

-46.99%

S

2008-06-20

2008-06-24 16:25:05

officer (Chief Operating Officer)

400

$11.54

$4,616.00

58,549

-21.84%